Protein Details: Amiloride-sensitive sodium channel subunit gamma
Protein ID
ICDB_Pro_0579
Protein Name
Amiloride-sensitive sodium channel subunit gamma
Gene Name
SCNN1G
Organism
Homo sapiens (Human)
Length
649 amino acids
AlphaFoldDB
AF-P51170-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water;which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis;but also in airway surface liquid homeostasis;which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney;colon;lung and sweat glands. Also plays a role in taste perception.
Sequence
Ligand Binding
Binding Site
Disease
Bronchiectasis With Or Without Elevated Sweat Chloride 3 and Liddle Syndrome 2
Location
Expressed in kidney (at protein level)
DOI ID
10.1006/geno.1995.1188; 10.1152/ajpcell.1995.268.5.c1157; 10.1210/jcem.87.7.8674; 10.1101/gr.2596504; 10.1074/jbc.271.42.26062; 10.1038/ng0995-76; 10.1074/jbc.272.23.14611; 10.1074/jbc.c000906200; 10.1152/ajprenal.00080.2002; 10.1038/ng0696-248; 10.1097/00004872-200212000-00017; 10.1111/j.1365-2265.2007.02967.x; 10.1074/jbc.m803931200; 10.1378/chest.08-2246; 10.1007/s00418-011-0904-1; 10.1074/jbc.m112.363382; 10.1152/ajplung.00103.2013; 10.2174/1874467211306010005; 10.1016/j.gene.2015.12.061; 10.1210/jcem.84.7.5857; 10.1038/10297; 10.1126/science.1133427; 10.1186/1465-9921-9-46
RefSeq
NP_001030.2